During development, large numbers of cells die by a process known as programmed cell death. This loss of cells plays a number of important roles, including the sculpting of the body form and the removal of vestigial tissues. Data obtained from a variety of organisms has suggested that a cell's ‘decision’ to die is a differentiative event, requiring the activation of specific sets of genes. Several putative ‘cell death’ genes have recently been cloned, and one has been identified as the (...) product of the polyubiquitin gene. Accumulation of ubiquitin has been observed not only during programmed cell death, but also in several neurodegenerative disorders, including Alzheimer's Disease. (shrink)

Wikipedia has challenged traditional notions about the roles of experts in the Internet Age. Section 1 sets up a paradox. Wikipedia is a striking popular success, and yet its success can be attributed to the fact that it is wide open and bottom-up. How can such a successful knowledge project disdain expertise? Section 2 discusses the thesis that if Wikipedia could be shown by an excellent survey of experts to be fantastically reliable, then experts would not need to be granted (...) positions of special authority. But, among other problems, this thesis is self-stultifying. Section 3 explores a couple ways in which egalitarian online communities might challenge the occupational roles or the epistemic leadership roles of experts. There is little support for the notion that the distinctive occupations that require expertise are being undermined. It is also implausible that Wikipedia and its like might take over the epistemic leadership roles of experts. Section 4 argues that a main reason that Wikipedia’s articles are as good as they are is that they are edited by knowledgeable people to whom deference is paid, although voluntarily. But some Wikipedia articles suffer because so many aggressive people drive off people more knowledgeable than they are; so there is no reason to think that Wikipedia’s articles will continually improve. Moreover, Wikipedia’s commitment to anonymity further drives off good contributors. Generally, some decisionmaking role for experts is not just consistent with online knowledge communities being open and bottom-up, it is recommended as well. (shrink)

ABSTRACT Alchemy now holds an important place in the history of science. Its current status contrasts with its former exile as a “pseudoscience” or worse and results from several rehabilitative steps carried out by scholars who made closer, less programmatic, and more innovative studies of the documentary sources. Interestingly, alchemy's outcast status was created in the eighteenth century and perpetuated thereafter in part for strategic and polemical reasons—and not only on account of a lack of historical understanding. Alchemy's return to (...) the fold of the history of science highlights important features about the development of science and our changing understanding of it. (shrink)

Corpus linguistics is becoming a respected method of statutory and constitutional interpretation in the United States over the past decade, yet it has also generated a backlash from a group of scholars that engage in empirical work. This essay attempts to demonstrate both the contributions and the risks of using linguistic corpora as a primary tool in legal interpretation. Its legitimacy stems from the fact that courts routinely state that statutory terms, when not defined as a matter of law, are (...) to be given their ordinary meaning. Judges have responded to this challenge, with the assistance of the linguistics community, by using corpora to determine which meanings are ordinary. However, legal analysts have not determined exactly what makes one meaning ordinary and another not ordinary. This gap has led to a level of disagreement in the field. Moreover, while linguists who engage in corpus linguistic analysis typically emphasize the importance of context, the legal application is peculiarly context-free, in keeping with legal philosophies that eschew reliance on reference to a law’s purpose and the intent of the legislature that enacted it. This move adds a political dimension to corpus analysis as a means of legal interpretation. Yet, the article concludes that by relying on a blend of general and specialized corpora, the legal system can substantially reduce the problem of contextualization, as some linguists and practitioners have already recognized. (shrink)

It is a tacit assumption among most contemporary American and British philosophers that the question of style in philosophy is, at most, an issue of peripheral importance. Although it is generally agreed that a well developed sense of style may make a philosopher’s work more accessible and thus be a factor in its acceptance by a wider audience, and although it seems self-evident to many that the apparent inaccessibility of much of continental philosophy is due in part to stylistic vagaries (...) to which it is particularly prone, few would accord to style an importance beyond this. Certainly style is not an integral part of a philosophical position. It is always possible in principle, so the dominant view today suggests, to separate the position being expressed from the style the author employs in expressing it. The position itself is equated with the body of propositions that the philosopher is asserting; the style in which these are expressed either has no bearing on the truth value of the propositions and is consequently irrelevant or else it can be incorporated into either the propositions themselves or the structure of the argument, in which case it is no longer primarily a stylistic consideration. In either case, a philosopher’s style is ultimately not integral to the position which he advances. (shrink)

This paper explores various methods of developing a website that caters to the pedagogical needs of an introductory ethics course. Incorporating web sites into the course curriculum allows students to access a range of journal articles, a database for relevant secondary materials, and links to helpful websites. Online educational spaces are also an important pedagogical tool to facilitate student discussion. The site can be use for a discussion board for students within the course and from different institutions that are interested (...) in similar topics. Students are able to upload their own research and discuss it with their peers without the direct presence of the instructor. (shrink)

ETHICS: A PLURALISTIC APPROACH TO MORAL THEORY, FIFTH EDITION provides a comprehensive yet clear introduction to the main traditions in ethical thought, including virtue ethics, utilitarianism, and deontology. Additionally, the book presents a conceptual framework of ethical pluralism to help students understand the relationship among various theories. Lawrence Hinman, one of today's most respected and accomplished educators in ethics and philosophy education, presents a text that gives students plentiful opportunities to explore ethical theory and their own responses to them, (...) using fascinating features such as the Ethical Inventory sections that appear at the beginning and the end of the text. End-of-chapter discussion questions, and the use of current issues and movies help students retain what they've learned and truly comprehend the subject matter. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version. (shrink)

The essay is an attempt to examine aspects of legal interpretation from an external, sociological point of view. “Interpretation”, in its normal juristic sense, is primarily a process in which decision‐makers with secondary legitimacy link their decisions to authority of primary legitimacy. The type of legitimacy which is dominant within the legal system greatly influences the style of interpretation ‐ in “closed” systems, where the stock of premises is fixed, “legalism” will abound. Legal interpretation is not concerned with what a (...) text really means, in any literal sense; and standards for judging legal interpretation are different from the standards of judging other forms of communication, for example, literature. Indeed, a judge can be considered great precisely because of his creative acts of misinterpretation. (shrink)

The Century between the death of Copernicus and the birth of Newton witnessed a major reshaping of traditional ways of viewing the universe. The Ptolemaic system was challenged by Copernican heliocentrism, the Aristotelian world was assailed by Galilean physics and revived atomism, and theology was troubled by the progressive distancing of God from the daily operation of His creation. Besides earning this era the title of ‘the Scientific Revolution’, the intellectual ferment of these times offered many world systems as successors (...) to the throne of crumbling Aristotelianism. (shrink)

For over a century before the establishment of English vernacular religious drama in cities of the north, there was a concerted effort by the papacy and episcopacy to eradicate or rechannel lay and clerical ludi that struck the establishment as more conducive to lechery, gluttony, and the mocking of sacred things than to worshipful remembrance of Christ's sacrifice or to meditation on man's lamentable condition. However, legislating a distinction between appropriate and inappropriate ludi was not easy. When Innocent III sought (...) to ban ludi theatrales among his clergy, his edict had to be glossed to assure religious communities that the pope did not oppose the decorous representation of certain topics — the story of Rachel, the Three Kings, and Herod. Since some of these ludi took place within monastic and other religious houses, not all the participants thought them objectionable, but English bishops, particularly Grosseteste and Grandisson, tried to put down raucous and inappropriate ludi — some of which they called miracula — whether they occurred within religious houses or among the laity. (shrink)

Shepard proposes that the human mind relies on screw displacement because of its adaptive simplicity and uniqueness. I discuss this hypothesis by assessing screw displacement with respect to (1) other plausible spatial transformations, (2) a variety of criteria for adaptive efficiency and utility, and (3) a variety of psychological conditions in which observed responses discriminate amongst alternative spatial procedures. [Shepard].

In recent years, a particular doctrine about forms of life has come to be associated with Wittgenstein's name by followers and critics of his philosophy alike. It is not a doctrine which Wittgenstein espoused or even, given his understanding of philosophy, one which he could have accepted; nor is it worthy of acceptance on its own merits. I shall here outline the standard interpretation of Wittgenstein's remarks on forms of life, consider the textual basis for such a reading of Wittgenstein, (...) present a more consistent reading of the texts, place the problem of forms of life within a wider philosophical context, and show the ways in which it is indeed possible to say that a form of life is wrong. In the process, I shall note some important similarities between Wittgenstein's actual position, Quine's analysis of scientific knowledge, and Hans-Georg Gadamer's claims about the fusion of horizons. (shrink)

I propose that primary conscious awareness arises from synchronized activity in dendrites of neurons in dorsal thalamic nuclei, mediated particularly by inhibitory interactions with thalamic reticular neurons. In support, I offer four evidential pillars: consciousness is restricted to the results of cortical computations; thalamus is the common locus of action of brain injury in vegetative state and of general anesthetics; the anatomy and physiology of the thalamus imply a central role in consciousness; neural synchronization is a neural correlate of consciousness.

An award-winning theoretical physicist and best-selling author of A Universe from Nothing traces the dramatic discovery of the counterintuitive world of reality, explaining how readers can shift their perspectives to gain greater understandings of our individual roles in the universe.